Promethazine is metabolized by means of the liver to various diverse inactive metabolites such as sulfoxides of promethazine, N-demethylpromethazine collectively with other glucuronides. Dependence and Addiction: Codeine includes a higher probable for dependence and dependancy. It should be used with warning, significantly in patients with a record of material abuse. https://muhammadi147ibu1.wikijournalist.com/user