Activation of neuronal CB1 receptors ends in inhibition of adenylyl cyclase and lowered neurotransmitter launch via blockade of voltage-operated calcium channels.[46,65,125] The activation of such signaling pathways by CB1 receptors and the large levels of these receptors on presynaptic terminals indicates that endocannabinoid stimulation of CB1 receptors suppresses neuronal excitability https://personal-injury-compensat11788.blogaritma.com/31237983/what-does-cannabinoids-mean