At this time, There's two styles of reports on itaconate: Irg1−/− macrophages as well as the regulatory outcome of itaconate derivatives. These two success were complementary and disclosed that the regulatory mechanisms of itaconate associated alkylation on Keap1 to activate Nrf2, succinate dehydrogenase inhibition, activating transcription aspect three (ATF3) induction https://lycorine65432.tokka-blog.com/29969796/tgf-beta-1-protein-fundamentals-explained