TAK-243 preferentially certain to UBA1 in excess of the associated E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 lessened levels of ubiquitylated proteins, increased markers of proteotoxic anxiety and DNA destruction anxiety. In vivo, TAK-243 decreased leukemic load and qualified leukemic stem cells https://edmundl308ycg0.buyoutblog.com/profile