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Opioid activity is because of the two minimal affinity binding of your guardian compound and higher affinity binding on the O-demethylated metabolite M1 to μ-opioid receptors. In animal versions, M1 is nearly 6 situations a lot more strong than tramadol in making analgesia and two hundred moments additional strong in https://legaltramadols.com/product/buy-tramadol-50-mg/

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