Pretreatment with probenecid cuts down the two the natriuresis and hyperreninemia produced by Bumex. This antagonistic effect of probenecid on Bumex natriuresis just isn't on account of a immediate action on sodium excretion but is probably secondary to its inhibitory impact on renal tubular secretion of bumetanide. Therefore, probenecid shouldn't http://bomex09641.blogzag.com/20978899/how-can-save-you-time-stress-and-money